解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We have examined the linkage relationships between five biochemical markers, Acon-1, Ahd-2, Ahd-c, Akp-1, and Hao-1, and 19 other genetic loci in five breeding combinations. The genetic locus that codes for a recently described aldehyde dehydrogenase in the liver (Ahd-c) has been assigned to linkage group X (LG X). Hy...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00502790
更新日期:1986-04-01 00:00:00
abstract::In vitro DNA:DNA hybridizations and hydroxyapatite thermal-elution chromatography were employed to identify the diploid Triticum species ancestral to the B genome of T. turgidum. Unique and repeated sequences from the various Triticum species were separated by hybridization and thermal elution on hydroxyapatite. Uniqu...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00502977
更新日期:1986-02-01 00:00:00
abstract::The ribosomal RNA cistrons of three species of trout: Salvelinus namaycush (lake trout), Salvelinus fontinalis (brook trout), and Salmo gairdneri (rainbow trout) were examined by Southern blot analysis of genomic DNA. The repeat length of the cistron of S. namaycush is 26 kb. A repeat-length polymorphism was observed ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499943
更新日期:1985-12-01 00:00:00
abstract::Using two-dimensional gel electrophoresis, we have analyzed proteins from a plasma membrane-enriched fraction from Phycomyces sporangiophores. Specifically, we have compared gels for night-blind mutants and a wild-type strain to find proteins involved in the early steps of the sensory transduction chain for phototropi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499081
更新日期:1985-06-01 00:00:00
abstract::The immunological cross-reactivity of heterogeneous acid phosphatase isozymes from different human tissues has been studied using monospecific antisera prepared against four homogeneous acid phosphatases. The enzyme characterized as tartrate-inhibitable, prostatic acid phosphatase is also found to be present in leukoc...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00504327
更新日期:1985-04-01 00:00:00
abstract::Starch gel electrophoresis of creatine kinase (CK) isozymes of Xenopus tropicalis shows that at least two different genes code for CK in this diploid (2n = 20) species. These genes seen to be orthologous to the CK-A and CK-C genes of extant crossopterygian fish. Additional isozymes may be interpreted either as product...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499114
更新日期:1985-02-01 00:00:00
abstract::A new polymorphism, Pc, has been identified in human saliva. Two proteins, Pc 1 and Pc 2, are determined by alleles Pc1 and Pc2, respectively, which show autosomal codominant inheritance. No null phenotype has been encountered in 225 randomly collected salivas. The frequencies of the two alleles differ in the Black an...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499111
更新日期:1985-02-01 00:00:00
abstract::Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catechol and phenolic drugs and xenobiotic compounds. Platelets and other tissues contain at least two forms of PST, forms that have been designated the "TL" and the "TS" forms. We measured the thermal stability of platelet TS PST in blood samples from...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499627
更新日期:1984-12-01 00:00:00
abstract::A mouse mutant with pyruvate kinase (PK) hyperactivity has been found in offspring of 1-ethyl-1-nitrosourea (ENU)-treated male mice. The activity alteration was detected in the blood and could also be found in the liver but not in the muscle, kidney, heart, spleen, lung, or brain. Heterozygous mice have erythrocyte PK...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499635
更新日期:1984-12-01 00:00:00
abstract::Larval serum protein-1 (LSP-1) and LSP-2 are the major proteins of Drosophila larval serum. The amount of LSP-1 synthesized is strictly proportional to the number of LSP-1 genes present within the range 1-10. The normal number in female flies is 6. Flies with extreme amounts of LSP-1 were, by our criteria, as fit as t...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499473
更新日期:1984-10-01 00:00:00
abstract::The extent of naturally occurring variations of enzyme locus expression was determined for three tissues (liver, muscle, and eye) in two species of sunfish (Centrarchidae), the green sunfish (Lepomis cyanellus) and the redear sunfish (L. microlophus). The genetic basis for species differences in tissue enzyme specific...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499484
更新日期:1984-10-01 00:00:00
abstract::The molecular nature of chicken fetal antigen (CFA) and quail fetal antigen (QFA) was studied on embryonic red blood cells (RBCs) of the chicken, the Japanese quail, and the quail-chicken hybrid. Specific immunoprecipitation of radiolabeled membrane proteins followed by electrophoretic separation and autoradiography w...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499476
更新日期:1984-10-01 00:00:00
abstract::Alcohol dehydrogenase from Drosophila funebris and D. immigrans is evident at all developmental stages. The highest activity level appears in third-instar larvae and declines to a lower level at all later stages of development. Both species are monomorphic. The enzyme is a dimer consisting of two identical subunits wi...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499474
更新日期:1984-10-01 00:00:00
abstract::The inducibility of alcohol dehydrogenase (ADH) has been recognized in different systems including maize, Drosophila, and mice. Our earlier results showed strain-specific ADH responses to chronic ethanol administration relative to matched littermate controls in mice. For this study we used two strains which showed "in...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00485847
更新日期:1984-08-01 00:00:00
abstract::The concentration of mouse kidney histidine decarboxylase (HDC) is modulated by estrogen, testosterone, and thyroxine in a tissue-specific manner. Variation in HDC levels between strains of mice can be used to investigate the genetic regulation of enzyme structure, tissue specific expression, and induction and repress...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00485850
更新日期:1984-08-01 00:00:00
abstract::The autoregulation of testicular luteinizing hormone (LH) receptors was studied in hypogonadal (hpg/hpg) and normal mice. The basal concentration of LH receptors was more than three-fold higher in hpg/hpg than in normal mice. After injection of hCG, hpg/hpg mice showed a decrease in LH receptor levels which was not ob...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484511
更新日期:1984-06-01 00:00:00
abstract::A survey of laboratory strains of Anopheles stephensi for nonspecific esterases by polyacrylamide gel electrophoresis revealed 10 zones of esterase activity. In 3 of the 10 zones, three electromorphs were observed. Genetic analysis revealed that these three zones are controlled by three loci, viz., Est-3, Est-4, and E...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484518
更新日期:1984-06-01 00:00:00
abstract::Glutamate-oxaloacetate transaminase (GOT; EC 2.6.1.1) occurs as two electrophoretically distinguishable isozymes in the copepod Tigriopus californicus. The slower-migrating form, referred to as GOT2 , is shown to be associated with the mitochondrial cell fraction. GOT2 phenotypes are inherited in typical Mendelian fas...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484232
更新日期:1984-04-01 00:00:00
abstract::Liver homogenate-supernatants from most Japanese exhibit an "atypical" pH optimum for ethanol oxidation at pH 8.8 instead of 10.5, the "typical" pH-activity optimum. It has been proposed that atypical livers contain alcohol dehydrogenase isozymes with beta 2 subunits while typical livers contain isozymes with beta 1 s...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499296
更新日期:1984-02-01 00:00:00
abstract::Environmentally induced flax genotrophs L and S show heritable shifts in the relative mobilities of peroxidase, esterase, and acid phosphatase isozymes, plus a number of nonspecific glycoproteins. All L isozymes migrated faster than corresponding S isozymes in 10% acrylamide gels. Various aspects of these shifts are r...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499290
更新日期:1984-02-01 00:00:00
abstract::Restriction endonuclease analyses of DNA from one Black G gamma A gamma-HPFH homozygote and four Black and one Indian G gamma A gamma-HPFH heterozygotes have identified three different HPFH types which are the result of large deletions including the delta and beta genes. Two of the types are comparable to those charac...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499284
更新日期:1984-02-01 00:00:00
abstract::Two alleles are encoded at the malate dehydrogenase locus in largemouth bass, Micropterus salmoides. Populations in the extreme northern areas of the range of this fish are fixed or nearly fixed for the B1 allele, whereas populations in Florida are fixed for the alternative allele, B2. The MDH-B1B1 and MDH-B2B2 alleli...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00488466
更新日期:1983-12-01 00:00:00
abstract::Linkage data for the sex-linked malic enzyme (Me) and hexokinase-1 (Hk-1) loci in the flour beetle, Tribolium confusum, were obtained from a three-point experiment involving the red locus. The order of the three loci was determined to be red--Hk-1-Me, with map distances of 12.4 +/- 1.8 for red to Hk-1 and 7.0 +/- 1.3 ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00498914
更新日期:1983-08-01 00:00:00
abstract::Electrophoretic variation of sorbitol dehydrogenase has been found in Mus musculus; the SDH-1 A phenotype migrates further toward the cathode under the conditions used than the SDH-1B phenotype. Mice with the SDH-1B phenotype have enzyme activity reduced to 25% of that found in mice with the SDH-1A phenotype, but no d...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00498928
更新日期:1983-08-01 00:00:00
abstract::Using megagametophyte (maternal haploid) and embryo (diploid) tissues of incense-cedar seeds, the expression of one of three malate dehydrogenase (MDH) loci was found to be influenced by a second, unlinked, modifier locus. Whereas alleles of the affected structural locus are codominant, the modifier alleles show domin...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484435
更新日期:1983-06-01 00:00:00
abstract::We have shown in our previous work that in the tetraploid loach Misgurnus fossilis carboxylesterase-2 (E-2) phenotypes of embryos and early larvae are controlled by the alleles of the Est-2 locus. In the present work it has been established that the somatic tissues of many adult fish homozygous for one of the Est-2 al...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484449
更新日期:1983-06-01 00:00:00
abstract::A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activit...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00499142
更新日期:1983-04-01 00:00:00
abstract::The structural characterization of a third type of alpha chain, detected in the hemoglobin of sheep also possessing the alpha Leu and the II alpha His chains, is reported. The new alpha-chain variant is an allele of the common alpha Leu chain controlled by the 1 alpha locus and differs from it in the replacement of th...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF02395389
更新日期:1983-02-01 00:00:00
abstract::Prolamin mixtures were isolated from oats, rice, normal and high-lysine sorghum, two varieties of pearl millet, two strains of teosinte, and gamma grass and subjected to NH2-terminal amino acid sequence determinations. In each case (except for rice, whose prolamins apparently have blocked or unavailable NH2-terminal r...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00498931
更新日期:1982-12-01 00:00:00
abstract::Soluble starch synthase and branching enzyme were purified from 18-day-old cotyledons of the smooth-seeded pea cultivar Alaska (RR) and wrinkled-seeded pea cultivar Progress #9 (rr) by DEAE-cellulose chromatography. Two coeluting peaks of primed and citrate-stimulated starch synthase activity and a major and minor pea...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484061
更新日期:1982-10-01 00:00:00
abstract::Arylsulfatase A (ASA) activity was studied from five blood fractions, leukocytes plus platelets (LKPL), leukocytes (LK), neutrophils (N), lymphocytes (LYM), and platelets (PL). No significant difference was found among the mean ASA specific activity values for the fractions. Electrophoretic examination revealed four d...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484068
更新日期:1982-10-01 00:00:00
abstract::We report a new enzyme xylose dehydrogenase, the structural locus for which is on chromosome 7 of the mouse, closely linked to Tam-1. Three alleles have been detected in both laboratory strains and wild populations. Two of these determine proteins differing in electrophoretic mobility and the third is a "null." This e...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483970
更新日期:1982-08-01 00:00:00
abstract::Allelic frequencies at five polymorphic loci were determined in seven European and six Afrotropical populations of Drosophila melanogaster. African populations, which may be considered as ancestral for the species, showed a greater genetic diversity as measured by the number of alleles found. Within each geographic gr...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483971
更新日期:1982-08-01 00:00:00
abstract::Three dipeptidases in Drosophila melanogaster are under independent genetic control and their structural genes have been localized, Dip-A to 2R and Dip-B and Dip-C to 3R (Voelker and Langley, 1978; Ohnishi and Voelker, 1981). These enzymes were characterized with respect to their substrate specificities, genetic varia...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484692
更新日期:1982-06-01 00:00:00
abstract::The primary structures of the alpha globins from CE/J, DBA/2J, and a stock of Potter's mice were determined to identify the amino acid substitutions associated with the unique isoelectric focusing patterns of these hemoglobins. In addition, the primary structures of the alpha globins from MOL III and PERU mice were st...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484946
更新日期:1982-02-01 00:00:00
abstract::Two complementing loci in different linkage groups of the basidiomycete Ustilago violacea are involved in urease activity: a structural one (ure-1) and a second inferred to involve a permease (ure-2) locus. Two types of complementing mutations occur in the structural locus: null activity (ure-la) and obviously reduced...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484568
更新日期:1981-12-01 00:00:00
abstract::The highly active esterases A' and B that cannot be dissociated from OP resistance in Culex pipiens from France and California are shown to have equivalent Km values (2.1 x 10(-6) M/min/mosquito) but different turnover rates (Vm = 2.13 and 0.57 x 10(-6) M/min/mosquito, respectively) and pH for maximum activity. Both ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00504256
更新日期:1981-10-01 00:00:00
abstract::A new variant of hereditary hemolytic anemia in a family due to high adenosine triphosphate (ATP) is reported. The increase in ATP levels varied from 83 to 105% in the family members. Low 2,3-diphosphoglycerate levels and low 2,3-diphosphoglyceromutase activity were observed in three family members, with normal glucos...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00504264
更新日期:1981-10-01 00:00:00
abstract::Following starch gel electrophoresis and a modified staining method, three distinct groups of acid phosphatase isozymes (AP-1, AP-2, and AP-3) have been identified in scutellum extracts of different inbred maize lines. The AP-2 group includes three electrophoretic variants: a fast (F), an intermediate (I), and a slow ...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00483996
更新日期:1981-08-01 00:00:00
abstract::A null mutation at the phosphoglucomutase locus (Pgm-1) was discovered by electrophoretic analysis of the inbred mouse strain C57BL/6J. The null allele (Pgm-1n) was shown to segregate as a Mendelian unit alternative to the Pgm-1a and Pgm-1b alleles. Mice expressing the Pgm-1n allele, either in the heterozygous or homo...
journal_title:Biochemical genetics
pub_type: 杂志文章
doi:10.1007/BF00484629
更新日期:1981-06-01 00:00:00